SEMAX

EMAX is a synthetic heptapeptide (sequence: Met-Glu-His-Phe-Pro-Gly-Pro) derived from a fragment of adrenocorticotropic hormone (ACTH 4–10). It was originally developed as a neuroactive research peptide to study neuroprotection, cognitive modulation, and neurotrophic signaling mechanisms without hormonal side effects. In pre-clinical and in-vitro studies, SEMAX has been observed to influence brain-derived neurotrophic factor (BDNF) expression, dopaminergic and cholinergic signaling, and oxidative stress responses. These properties make it a valuable model compound for exploring neuroregeneration, synaptic plasticity, and stress adaptation pathways in the central nervous system.

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